Acetilsalicilna kislina: razlika med redakcijama

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m
| legal_UK = GSL
| legal_US = OTC
| routes_of_administration = Najpogosteje peroralno, pa tuidi rektalno; [[lizin acetilsalicilat]] se lahko da [[intravenoznaintravensko terapijazdravljenje|i. v.]] ali [[intramuskularna injekcija|i. m.]]
 
<!--Pharmacokinetic data-->
 
Aspirin ima tudi [[antitrombotik|antitrombotične]] učinke, posredovane prek zaviranja tvorbe [[tromboksan]]a, ki sicer medsebojno povezuje [[trombocit]]ne molekule, s čimer se tvori strdek nad poškodovano žilno steno. Ker lahko trombocitni strdek postane prevelik in ovira pretok krvi, se aspirin v nizkih odmerkih uporablja tudi dolgotrajno za preprečevanje [[miokardni infarkt|srčnega infarkta]], [[možganska kap|možganske kapi]] in tvorbe [[tromb|krvnih strdkov]] pri ljudeh, ki so nagnjeni k temu.<ref>{{navedi revijo| doi = 10.1056/NEJM198308183090703| issn = 00284793| volume = 309| issue = 7| pages = 396–403| last = Lewis| first = H D
| coauthors = J W Davis, D G Archibald, W E Steinke, T C Smitherman, J E Doherty, H W Schnaper, M M LeWinter, E Linares, J M Pouget, S C Sabharwal, E Chesler, H DeMots| title = Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study| journal = The New England Journal of Medicine| date = 18. avgusta 1983| pmid = 6135989}}</ref> V nizkih odmerkih se lahko aspirin uporabouporabi takoj po srčnem infarktu za preprečitev ponovnega infarkta ali odmrtja srčnega tkiva.<ref name="anticoag">{{navedi revijo|last = Julian|first = D G|coauthors = D A Chamberlain, S J Pocock|title = A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial|journal = BMJ| volume = 313|issue = 7070|pages = 1429–1431|publisher = British Medical Journal|date = 24. septembra 1996|pmid = 8973228|pmc = 2353012|doi = 10.1136/bmj.313.7070.1429}}</ref><ref>{{navedi revijo| volume = 92| issue = 10| pages = 2841–2847| last = Krumholz| first = Harlan M.| coauthors = Martha J. Radford, Edward F. Ellerbeck, John Hennen, Thomas P. Meehan, Marcia Petrillo, Yun Wang, Timothy F. Kresowik, Stephen F. Jencks| title = Aspirin in the Treatment of Acute Myocardial Infarction in Elderly Medicare Beneficiaries : Patterns of Use and Outcomes| journal = Circulation| year = 1995|pmid = 7586250| doi = 10.1161/01.CIR.92.10.2841}}</ref>
Aspirin lahko tudi učinkovito preprečuje nekatere vrste raka, zlasti [[kolorektalni rak]] (rak širokega črevesa in danke).<ref name="thelancet.com">{{cite journal|doi=10.1016/S1470-2045(12)70112-2|title=Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials|year=2012|last1=Algra|first1=Annemijn M|last2=Rothwell|first2=Peter M|journal=The Lancet Oncology|url=http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2812%2970112-2/abstract|volume=13|issue=5|pages=518–27|pmid=22440112}}</ref><ref name="thelancet.com"/><ref>{{cite journal|doi=10.1016/S0140-6736(11)61720-0|title=Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials|year=2012|last1=Rothwell|first1=Peter M|last2=Price|first2=Jacqueline F|last3=Fowkes|first3=F Gerald R|last4=Zanchetti|first4=Alberto|last5=Roncaglioni|first5=Maria Carla|last6=Tognoni|first6=Gianni|last7=Lee|first7=Robert|last8=Belch|first8=Jill FF|last9=Wilson|first9=Michelle|journal=The Lancet|volume=379|issue=9826|pages=1602}}</ref><ref>{{navedi revijo|doi=10.1016/S0140-6736(12)60209-8|title=Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials|year=2012|last1=Rothwell|first1=Peter M|last2=Wilson|first2=Michelle|last3=Price|first3=Jacqueline F|last4=Belch|first4=Jill FF|last5=Meade|first5=Tom W|last6=Mehta|first6=Ziyah|journal=The Lancet|volume=379|issue=9826|pages=1591}}</ref>
 
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