Humani koronavirus 229E

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Humani koronavirus 229E
Znanstvena klasifikacija
Vrsta: Humani koronavirus 229E

Humani koronavirus 229E (HCoV-229E) je virus z enoverižno, pozitivno umerjeno RNK iz rodu alfakoronavirusov v poddružini koronavirusov. Humani koronavirus 229E in njemu sorodni humani koronavirus OC43 sta pogosta povzročitelja navadnega prehlada.[1][2]

Prenašanje[uredi | uredi kodo]

HCoV-229E se prenaša kapljično ter preko okuženih predmetov in tudi preko oči in dihal.

Znaki in simptomi[uredi | uredi kodo]

HCoV-229E lahko povzroči različne simptome na dihalih, od navadnega prehlada do smrtonosne pljučnice ali bronhiolitisa. Pogosto je bolnik sookužen še z drugimi respiratornimi virusi, kot je humani respiratorni sincicijski virus (HRSV).[3][4][5]

Epidemiologija[uredi | uredi kodo]

HCoV-229E je eden od sedmih poznanih koronavirusov, ki povzročajo bolezni pri človeku. HCoV-229E je poleg HCoV-NL63, HCoV-OC43 in HCoV-HKU1 razširjen po vsem svetu;[6][7] v različnih obdobjih se pojavljajo v različnih območjih.[8][9][10]

Sklici[uredi | uredi kodo]

  1. Susanna K. P. Lau, Paul Lee, Alan K. L. Tsang, Cyril C. Y. Yip,1 Herman Tse, Rodney A. Lee, Lok-Yee So, Yu-Lung Lau, Kwok-Hung Chan, Patrick C. Y. Woo, and Kwok-Yung Yuen. Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a Novel Genotype due to Natural Recombination. J Virology. 2011 November; 85(21): 11325–11337.
  2. E. R. Gaunt,1 A. Hardie,2 E. C. J. Claas,3 P. Simmonds,1 and K. E. Templeton. Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method down-pointing small open triangle. J Clin Microbiol. 2010 August; 48(8): 2940–2947.
  3. Pene, F., A. Merlat, A. Vabret, F. Rozenberg, A. Buzyn, F. Dreyfus, A. Cariou, F. Freymuth, and P. Lebon. 2003. Coronavirus 229E related pneumonia in immunocompromised patients. Clin. Infect. Dis. 37:929-932. [PubMed]
  4. Vabret, A., T. Mourez, S. Gouarin, J. Petitjean, and F. Freymuth. 2003. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin. Infect. Dis. 36:985-989. [PubMed]
  5. Woo, P. C. Y., S. K. P. Lau, H. Tsoi, Y. Huang, R. W. S. Poon, C. M. Chu, R. A. Lee, W. K. Luk, G. K. M. Wong, B. H. L. Wong, V. C. C. Cheng, B. S. F. Tang, A. K. L. Wu, R. W. H. Yung, H. Chen, Y. Guan, K. H. Chan, and K. Y. Yuen. 2005. Clinical and molecular epidemiological features of coronavirus HKU1 associated community acquired pneumonia. J. Infect. Dis. 192:1898-1907. [PubMed]
  6. Fields, B. N., D. M. Knipe, and P. M. Howley (ed.). 1996. Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, PA.
  7. van der Hoek, L., P. Krzysztof, and B. Berkhout. 2006. Human coronavirus NL63, a new respiratory virus. FEMS Microbiol. Rev. 30:760-773. [PubMed]
  8. Esper, F., C. Weibel, D. Ferguson, M. L. Landry, and J. S. Kahn. 2006. Coronavirus HKU1 infection in the United States. Emerg. Infect. Dis. 12:775-779. [PMC free article] [PubMed]
  9. Gerna, G., E. Percivalle, A. Sarasini, G. Campanini, A. Piralla, F. Rovida, E. Genini, A. Marchi, and F. Baldanti. 2007. Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients. J. Clin. Virol. 38:244-250. [PubMed]
  10. Kaye, H. S., H. B. Marsh, and W. R. Dowdle. 1971. Seroepidemiologic survey of coronavirus (strain OC 43) related infections in a children's population. Am. J. Epidemiol. 94:43-49. [PubMed]