Ogled vira Bradikinin

{{chembox
| Watchedfields = changed
| verifiedrevid = 443425952
|ImageFile=Bradykinin structure.svg
|ImageFile1=Bradykinin updated.png
|ImageSize=250px
|ImageSize1=250px
|IUPACName=
|OtherNames=
|Section1= {{Chembox Identifiers
|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 388341
| InChI = 1/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
| InChIKey = QXZGBUJJYSLZLT-FDISYFBBBG
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 406291
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QXZGBUJJYSLZLT-FDISYFBBSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=58-82-2
|  PubChem = 439201
| IUPHAR_ligand = 649
|  UNII_Ref = {{fdacite|correct|FDA}}
| UNII = S8TIM42R2W
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 3165
| SMILES = O=C(N[C@H](C(=O)N[C@H](C(=O)O)CCC/N=C(\N)N)Cc1ccccc1)[C@H]5N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]3N(C(=O)[C@H]2N(C(=O)[C@@H](N)CCC/N=C(\N)N)CCC2)CCC3)Cc4ccccc4)CO)CCC5
|  MeSHName=Bradykinin
  }}
|Section2= {{Chembox Properties
|  C=50|H=73|N=15|O=11
|  Appearance=
|  Density=
|  MeltingPt=
|  BoilingPt=
|  Solubility=
  }}
}}
{{infobox protein
|Name=[[kininogen 1]]
|caption=
|image=
|width=
|HGNCid=6383
|Symbol=[[kininogen 1|KNG1]]
|AltSymbols=KNG, BDK
|EntrezGene=3827
|OMIM=612358
|RefSeq=NM_001102416
|UniProt= P01042
|PDB=
|ECnumber=
|Chromosome=3
|Arm=q
|Band=21
|LocusSupplementaryData=-qter
}}

'''Bradikinín''' je [[nonapeptid]]ni [[vnetni posrednik]].<ref name=SMS>https://www.termania.net/slovarji/slovenski-medicinski-slovar/5508628/bradikinin?dictionaries=95&query=bradikinin&SearchIn=All, Slovesnki medicinski e-slovar, vpogled: 15. 6. 2020.</ref> Preko bradikininskih receptorjev povzroča [[vazodilatacija|vazodilatacijo]] in povečano prepustnost žilja,<ref>Rupnik E. s sod. Življenje ogrožajoči angioedem po zaviralcu angiotenzinove konvertaze – Prikaz dveh primerov. Zdrav Vestn 2015; 84: 866–870.</ref> povzroča pa tudi [[bolečina|bolečino]] ter krči [[gladko mišičje]] [[bronhus]]ov in [[črevo|črevesa]].<ref name=SMS/>

Zdravila iz skupine [[zaviralci angiotenzin pretvarjajočega encima|zaviralcev angiotenzin pretvarjajočega encima]], ki se uporabljajo za zdravljenje [[povišan krvni tlak|povišanega krvnega tlaka]] in [[srčno popuščanje|srčnega popuščanja]], zavirajo razgradnjo bradikinina, zvišujejo njegove ravni v krvi in tako povečujejo učinek znižanja tlaka. 

== Zgradba ==
Bradikinin je nonapeptid, torej sestoji iz peptidne verige z devetimi [[aminokislina]]mi. Njihovo zaporednje je: [[arginin|Arg]]-[[prolin|Pro]]-[[prolin|Pro]]-[[glicin|Gly]]-[[fenilalanin|Phe]]-[[serin|Ser]]-[[prolin|Pro]]-[[fenilalanin|Phe]]-[[arginin|Arg]] (RPPGFSPFR). Empirična formula bradikinina je C<sub>50</sub>H<sub>73</sub>N<sub>15</sub>O<sub>11</sub>.

== Sklici ==
{{sklici}}

{{normativna kontrola}}
[[Kategorija:Peptidi]]